Formulation & Quality Control Senior Scientist/ Scientist_Ref. PDFQC_20

Biology · Cambridge, Cambridgeshire
Department Biology
Employment Type Full-Time
Minimum Experience Experienced

The Company

 

Evonetix is a growing biotech company which is set to revolutionize de novo gene synthesis as needed to facilitate the fast-growing and incredibly exciting field of synthetic biology.  Our technology integrates chemistry, molecular biology and microfluidics with a novel silicon array, manufactured with semiconductor microfabrication techniques and capable of independent control of many thousands of miniaturized reaction sites. This allows massive parallelism of the DNA synthesis process and on-chip gene assembly with integrated error removal.

Our community is a closely-knit multidisciplinary and multicultural team of biologists, physicists, chemists and engineers.

We have closed our $30M Series B funding round and moved to a state-of-the-art facility in central Cambridge, allowing us to undertake significant recruitment to enable the development of our commercial desktop DNA synthesiser.

 

 

The Position

 

Our novel DNA synthesis approach is based on re-engineered phosphoramidite chemistry that can be thermally controlled by the miniaturised reaction sites of our silicon array.  We have demonstrated all the elements of our proprietary technology and are beginning to design our first desktop DNA synthesiser.

 

We are looking for an experienced formulation & quality control senior scientist/ scientist to work in our product development multi-disciplinary team, to translate the chemical and biological components and processes from research into production.

 

You will be responsible for ensuring the quality of the chemical and biological components that ultimately go into our products and for acting as the bridge between our multidisciplinary R&D team and our contract manufacturers; managing the scale-up and delivery of enzymes for production and developing bioassays for their quality control.  You need to have a deep attention for detail and expect not to compromise on quality. You will also contribute to the system design of our first product, and to the plan and delivery of a programme of experimental work to characterise the inputs and output of our instruments and optimise product performance. 

 

This is a unique opportunity to contribute towards the development of Evonetix’s third-generation gene synthesis platform.

 

 

Essential skills and experience


  • Educated to PhD level in Molecular Biology, Biochemistry, Biotechnology, Biochemical Engineering, or related subject in Biosciences
  • Experience in developing, implementing and documenting quality control assays and specifications for enzyme formulations to validate inputs and output of our instruments
  • Experience designing and optimising enzyme formulations to achieve commercial levels of stability, robustness and performance
  • Proficient in molecular biology and analytical methods for nucleic acid manipulation and analysis, including PCR, qPCR, detection, purification and quantification
  • Experience developing functional enzyme assays
  • Experience in product development processes; from requirements definition, analysis, architecture design, integration, verification/validation and manufacturing
  • A successful candidate will be a self-starter, able to work both independently and within a multidisciplinary team, to meet tight deadlines
  • Highly collaborative, self-motivated, team player with excellent verbal and written communication skills

 

 

Desirable skills

 

Candidates would have an advantage if they can demonstrate some of these skills:

 

  • Hands-on experience with DNA-based assays in microfluidic environments 
  • Hands-on experience with sequencing technologies and/or DNA microarrays
  • Hands-on experience with lyophilisation techniques applied to enzymes
  • Experience with large-scale production of enzymes
  • Experience with oligonucleotide and DNA synthesis, either chemically or enzymatically

 

 

Benefits

 

This opportunity comes with an attractive benefits package which includes a contributory pension, private medical care, life assurance as well as the opportunity to partake in the staff equity scheme.  

Thank You

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  • Location
    Cambridge, Cambridgeshire
  • Department
    Biology
  • Employment Type
    Full-Time
  • Minimum Experience
    Experienced